At the International Iberian Nanotechnology Laboratory, INL, research activities addressing the current COVID-19 outbreak have been fortified through a concerted action recruiting multi-disciplinary resources at the service of the current needs of the society, primarily related to the development of rapid diagnostics systems. We have joined forces with several institutions and authorities in Portugal, Spain and other countries in order to accelerate the deployment of novel detection schemes.

Several initiatives are ongoing:

• To respond to the immediate challenges faced by the public healthcare service, INL is importing fast paper-based tests for their validation and rapid deployment in collaboration with ICVS, University of Minho, Hospital de Braga and Invest Braga. These low-cost tests can detect the presence of antibodies in asymptomatic individuals that have been in contact with the virus.  Combined with an app that can send the test results to the authorities, the implementation of these kits at population scale would enable the return to the work force to potentially immune individuals at no risk.

• INL is working on the development of faster and miniaturized devices for decentralized analysis. Advanced Point-of-Care (POC) devices are being designed and tested including all steps of analysis namely DNA/RNA extraction and purification from complex samples such as a number of clinical samples, and amplification using isothermal amplification approaches such as LAMP or RPA. Different sampling strategies are being evaluated and tested to ensure a more representative sample from patients.

• Additionally, building on our previously developed technology for the analysis of cancer mutations, INL aims to develop a surface enhanced Raman spectroscopy (SERS)-microfluidic chip for fast amplification-free screening of SARS-CoV-2 at the point-of-care.